Tipping Tumor Microenvironment against Drug Resistance
نویسندگان
چکیده
منابع مشابه
Tipping Tumor Microenvironment against Drug Resistance
Tumor microenvironment (TME) represents a structural hallmark of solid neoplasms, and plays a critical role in multiple aspects of oncologic pathogenesis such as local invasion and immune escaping, thus substantially contributing to malignant metastasis and anti-cancer drug resistance. TME is composed of highly heterogeneous and dynamic components including vascular cells, immune network, adipo...
متن کاملDrug resistance and the solid tumor microenvironment.
Resistance of human tumors to anticancer drugs is most often ascribed to gene mutations, gene amplification, or epigenetic changes that influence the uptake, metabolism, or export of drugs from single cells. Another important yet little-appreciated cause of anticancer drug resistance is the limited ability of drugs to penetrate tumor tissue and to reach all of the tumor cells in a potentially l...
متن کاملThe complexity of microenvironment-mediated drug resistance
Since the FDA approval of vemurafenib for the treatment of disseminated melanoma in 2011, followed by approval of dabrafenib in 2013 and dabrafenib/trametinib combination in 2014, melanoma has become the poster child for targeted kinase therapy. Despite encouraging initial clinical responses, most patients ultimately develop drug resistance and relapse, prompting an enormous research effort foc...
متن کاملVascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.
Therapeutic targeting of the tumor vasculature that destroys preexisting blood vessels of the tumor and antiangiogenesis therapy capitalize on the requirement of tumor cells on an intact vascular supply for oxygen and nutrients for growth, expansion and metastasis to the distal organs. Whereas these classes of agents show promise in delaying tumor progression, they also create glucose and oxyge...
متن کاملThe bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance.
The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells. These cells are supported by fibroblast-like bone marrow stromal cells, osteoblasts, and osteoclasts which secrete soluble factors and extracellular matrix proteins that mediate these functions. This rich environment serves as a safe haven not only for normal and malignant hemat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Oncology Translational Research
سال: 2017
ISSN: 2476-2261
DOI: 10.4172/2476-2261.1000106